Cutting-Edge Virus-Host Interactome Discovery: A Multi-Omics AI Driven Approach (VIRHOSTAI)

Type: National Project Project

Duration: from 2021 Feb 01 to 2024 Jan 31

Financed by: FCT

Prime Contractor: Centro de Neurociências e Biologia Celular (Other)

The world is urgently needing new cutting-edge computational tools that can create useful knowledge from information that is being published in high rates in a fragmented manner, delivering more tailored therapies against recent and novel coronavirus outbreaks such as the current one, COVID-19. Despite the vast scientific and technological advances in Drug Research and Development (R&D), as well as the amount of time and funding involved, we are witnessing a steady decline in pharmaceutical productivity in the last decades due to: i) lack of safety - high toxicity and many side effects are still significant reasons why a large percentage of drugs fail at pre-clinical and clinical stages; ii) patient-related constraints - human biological complexity and high genomic variability leads to different responses to therapy at both the individual and population level; iii) target-related issues - target identification and validation are the main reason for project withdrawal in early-stages, mainly due to the lack of understanding of the complexity and multifactorial character of infectious diseases.

Partnerships

  • Centro de Neurociências e Biologia Celular (Other)
  • INESC-ID (Other)
  • IST-ID (University) -Portugal

Principal Investigators

Members