Inibição da patogénese e construção de fábricas celulares: por desenvolvimento de modelos regulatórios-metabólicos mistos à escala do genoma em leveduras (MIXEDUP)

Type: National Project

Duration: from 2018 Oct 01 to 2020 Dec 31

Financed by: FCT

Prime Contractor: IST-ID (University) -Portugal

This project proposes to use Systems Biology approaches and single cell eukaryotes as case studies, in order to design better ways to prevent and control superficial and invasive candidiasis, whose two prime causes are C. albicans and C. glabrata. Genome-scale regulatory models will be built for C. albicans and C. glabrata, using the data gathered at the PathoYeastract database, and the S. cerevisiae regulatory model as a cast (http://yeastract.com). Also, orthology relationships will be considered, extracted from CGD (http://www.candidagenome.org/) and PhylomeDB (http://phylomedb.org/). Finally, a reliable complete genome-scale integrated regulatory-metabolic model will be considered, connecting the metabolic and regulatory models for each of the three yeast species.

Partnerships

  • Fundação Calouste Gulbekian (Other)
  • INESC-ID (Other)
  • IST-ID (University) -Portugal
  • Universidade do Minho (University) - Braga, Portugal

Principal Investigators

Members